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simplified galactic cosmic ray simulation (simgcrsim)  (Brookhaven Instruments)

 
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    Brookhaven Instruments simplified galactic cosmic ray simulation (simgcrsim)
    Simplified Galactic Cosmic Ray Simulation (Simgcrsim), supplied by Brookhaven Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simgcrsim/space+radiation/pm39033285-557-1-6
    Average 90 stars, based on 1 article reviews
    simplified galactic cosmic ray simulation (simgcrsim) - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Irradiation:

    Article Title: Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development
    Article Snippet: tissue models were used to study vascular changes associated with specific miRNAs ( ). .. Irradiations were carried out at Brookhaven National Lab using 50cGy of SimGCRSim (5-ion simplified galactic cosmic ray simulation: protons at 1000MeV, 28 Si at 600 MeV/n, 4 He at 250 MeV/n, 16 O at 350 MeV/n, 56 Fe at 600 MeV/n, and protons at 250 MeV). .. A dose of 0.5 μm of each antagomir was administered to the appropriate groups 24 hours prior

    Staining:

    Article Title: Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development
    Article Snippet: tissue models were used to study vascular changes associated with specific miRNAs ( ). .. Irradiations were carried out at Brookhaven National Lab using 50cGy of SimGCRSim (5-ion simplified galactic cosmic ray simulation: protons at 1000MeV, 28 Si at 600 MeV/n, 4 He at 250 MeV/n, 16 O at 350 MeV/n, 56 Fe at 600 MeV/n, and protons at 250 MeV). .. A dose of 0.5 μm of each antagomir was administered to the appropriate groups 24 hours prior

    Inhibition:

    Article Title: Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development
    Article Snippet: tissue models were used to study vascular changes associated with specific miRNAs ( ). .. Irradiations were carried out at Brookhaven National Lab using 50cGy of SimGCRSim (5-ion simplified galactic cosmic ray simulation: protons at 1000MeV, 28 Si at 600 MeV/n, 4 He at 250 MeV/n, 16 O at 350 MeV/n, 56 Fe at 600 MeV/n, and protons at 250 MeV). .. A dose of 0.5 μm of each antagomir was administered to the appropriate groups 24 hours prior

    Control:

    Article Title: Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development
    Article Snippet: tissue models were used to study vascular changes associated with specific miRNAs ( ). .. Irradiations were carried out at Brookhaven National Lab using 50cGy of SimGCRSim (5-ion simplified galactic cosmic ray simulation: protons at 1000MeV, 28 Si at 600 MeV/n, 4 He at 250 MeV/n, 16 O at 350 MeV/n, 56 Fe at 600 MeV/n, and protons at 250 MeV). .. A dose of 0.5 μm of each antagomir was administered to the appropriate groups 24 hours prior



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    simplified galactic cosmic ray simulation (simgcrsim)  (Brookhaven Instruments)
    90
    Brookhaven Instruments simplified galactic cosmic ray simulation (simgcrsim)
    Simplified Galactic Cosmic Ray Simulation (Simgcrsim), supplied by Brookhaven Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simgcrsim/space+radiation/pm39033285-557-1-6
    Average 90 stars, based on 1 article reviews
    simplified galactic cosmic ray simulation (simgcrsim) - by Bioz Stars, 2026-10
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    simgcrsim  (Mimetas Inc)
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    Mimetas Inc simgcrsim
    FIGURE 3 Astrocytes exacerbate acute endothelial cell barrier permeability caused by simulated deep space radiation. (A–D). Vascular endothelial cell structure permeability 1 day after irradiation with 5-ion <t>SimGCRSim</t> (A, C) or 600 MeV/n 56Fe particles (B, D), quantified as area under the curve of relative fluorescence of dye. Dye, TRITC-conjugated 155 kDa dextran (A, B) or FITC-conjugated 40 kDa dextran (C, D). Endo, endothelial cells alone. Endo + astro, endothelial cells and astrocytes. Open bars, chips with endothelial cells only. Shaded bars, chips with endothelial cells and astrocytes. Blue, 0 Gy sham irradiation. Light red, lower dose (0.25 Gy SimGCRSim, 0.3 Gy 600 MeV/n 56Fe). Dark red, higher dose (0.5 Gy SimGCRSim, 0.82 Gy 600 MeV/n 56Fe). N = 8 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, Dunnett’s multiple comparison test, 2-way ANOVA. Non statistically significant changes are not marked.
    Simgcrsim, supplied by Mimetas Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simgcrsim/simgcrsim/pm36275678-123-16-14
    Average 86 stars, based on 1 article reviews
    simgcrsim - by Bioz Stars, 2026-10
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    simgcrsim  (Brookhaven Instruments)
    90
    Brookhaven Instruments simgcrsim
    (A) Quantification of miRNAs from a 3D culture of mature human microvessels with human umbilical vein endothelial cells (HUVECs) irradiated with 0.5 Gy of simplified simulated galactic cosmic rays <t>(SimGCRSim)</t> compared to sham irradiated samples 48 h after irradiation. All candidate miRNAs were examined, but only the miRNAs that seemed to respond differently for each group are shown. The error bars represent SEM. (B and C) Mature microvessels fixed and fluorescently stained with 5-(4,6-dichlorotriazinyl) aminofluorescein (DTAF) 48 h after SimGCRSim irradiation with or without antagomir-induced inhibition of miR-125b, miR-16, and let-7a starting at 24 h prior to irradiation. Scrambled version of the antagomir was used a vehicle control. (D) Summary of all the fold-change values for all experiments utilized in this manuscript (including both ddPCR and miRNA-seq data). (E) The summary of the overall impact of the miRNAs on the gene targets determined in through pathway analysis on the miRNA-seq data. The arrows indicate the degree of up- or downregulation, and the colors of the arrows indicate the significance (i.e., p values). The gray-shaded regions represent the 11-day time points after irradiation. The red-shaded miRNAs represent the miRNAs used for the antagomir experiments in (B) and (C).
    Simgcrsim, supplied by Brookhaven Instruments, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simgcrsim/simgcrsim/pmc08441986-379-11-5
    Average 90 stars, based on 1 article reviews
    simgcrsim - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    FIGURE 3 Astrocytes exacerbate acute endothelial cell barrier permeability caused by simulated deep space radiation. (A–D). Vascular endothelial cell structure permeability 1 day after irradiation with 5-ion SimGCRSim (A, C) or 600 MeV/n 56Fe particles (B, D), quantified as area under the curve of relative fluorescence of dye. Dye, TRITC-conjugated 155 kDa dextran (A, B) or FITC-conjugated 40 kDa dextran (C, D). Endo, endothelial cells alone. Endo + astro, endothelial cells and astrocytes. Open bars, chips with endothelial cells only. Shaded bars, chips with endothelial cells and astrocytes. Blue, 0 Gy sham irradiation. Light red, lower dose (0.25 Gy SimGCRSim, 0.3 Gy 600 MeV/n 56Fe). Dark red, higher dose (0.5 Gy SimGCRSim, 0.82 Gy 600 MeV/n 56Fe). N = 8 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, Dunnett’s multiple comparison test, 2-way ANOVA. Non statistically significant changes are not marked.

    Journal: Frontiers in immunology

    Article Title: Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.

    doi: 10.3389/fimmu.2022.864923

    Figure Lengend Snippet: FIGURE 3 Astrocytes exacerbate acute endothelial cell barrier permeability caused by simulated deep space radiation. (A–D). Vascular endothelial cell structure permeability 1 day after irradiation with 5-ion SimGCRSim (A, C) or 600 MeV/n 56Fe particles (B, D), quantified as area under the curve of relative fluorescence of dye. Dye, TRITC-conjugated 155 kDa dextran (A, B) or FITC-conjugated 40 kDa dextran (C, D). Endo, endothelial cells alone. Endo + astro, endothelial cells and astrocytes. Open bars, chips with endothelial cells only. Shaded bars, chips with endothelial cells and astrocytes. Blue, 0 Gy sham irradiation. Light red, lower dose (0.25 Gy SimGCRSim, 0.3 Gy 600 MeV/n 56Fe). Dark red, higher dose (0.5 Gy SimGCRSim, 0.82 Gy 600 MeV/n 56Fe). N = 8 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, Dunnett’s multiple comparison test, 2-way ANOVA. Non statistically significant changes are not marked.

    Article Snippet: To assess whether simulated deep space radiation has a similar effect, we exposed BBB OrganoPlates to SimGCRSim or 600 MeV/n 56Fe particles and quantified vascular endothelial permeability at 24 hours after irradiation.

    Techniques: Permeability, Irradiation, Comparison

    FIGURE 6 Simulated space radiation induces oxidative stress that is partially mitigated by astrocytes. (A–D) Quantification of secreted 8-oxo-dG in supernatants of chips seeded with endothelial cells only (open bars) and endothelial cells + astrocytes (shaded bars) 1 day (A, B) and 7 days (C, D) after irradiation with SimGCRSim (A, C) or 600 MeV/n 56Fe (B, D) particles. Blue, 0 Gy sham irradiation. Light red, lower dose (0.3 Gy 600 MeV/n 56Fe, 0.25 Gy SimGCRSim). Dark red, higher dose (0.82 Gy 600 MeV/n 56Fe, 0.5 Gy SimGCRSim). N = 12 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, 2-way ANOVA, Dunnett’s multiple comparison’s test. Non statistically significant changes are not marked.

    Journal: Frontiers in immunology

    Article Title: Astrocytes regulate vascular endothelial responses to simulated deep space radiation in a human organ-on-a-chip model.

    doi: 10.3389/fimmu.2022.864923

    Figure Lengend Snippet: FIGURE 6 Simulated space radiation induces oxidative stress that is partially mitigated by astrocytes. (A–D) Quantification of secreted 8-oxo-dG in supernatants of chips seeded with endothelial cells only (open bars) and endothelial cells + astrocytes (shaded bars) 1 day (A, B) and 7 days (C, D) after irradiation with SimGCRSim (A, C) or 600 MeV/n 56Fe (B, D) particles. Blue, 0 Gy sham irradiation. Light red, lower dose (0.3 Gy 600 MeV/n 56Fe, 0.25 Gy SimGCRSim). Dark red, higher dose (0.82 Gy 600 MeV/n 56Fe, 0.5 Gy SimGCRSim). N = 12 chips per condition. Error bars, mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001, 2-way ANOVA, Dunnett’s multiple comparison’s test. Non statistically significant changes are not marked.

    Article Snippet: To assess whether simulated deep space radiation has a similar effect, we exposed BBB OrganoPlates to SimGCRSim or 600 MeV/n 56Fe particles and quantified vascular endothelial permeability at 24 hours after irradiation.

    Techniques: Irradiation

    (A) Quantification of miRNAs from a 3D culture of mature human microvessels with human umbilical vein endothelial cells (HUVECs) irradiated with 0.5 Gy of simplified simulated galactic cosmic rays (SimGCRSim) compared to sham irradiated samples 48 h after irradiation. All candidate miRNAs were examined, but only the miRNAs that seemed to respond differently for each group are shown. The error bars represent SEM. (B and C) Mature microvessels fixed and fluorescently stained with 5-(4,6-dichlorotriazinyl) aminofluorescein (DTAF) 48 h after SimGCRSim irradiation with or without antagomir-induced inhibition of miR-125b, miR-16, and let-7a starting at 24 h prior to irradiation. Scrambled version of the antagomir was used a vehicle control. (D) Summary of all the fold-change values for all experiments utilized in this manuscript (including both ddPCR and miRNA-seq data). (E) The summary of the overall impact of the miRNAs on the gene targets determined in through pathway analysis on the miRNA-seq data. The arrows indicate the degree of up- or downregulation, and the colors of the arrows indicate the significance (i.e., p values). The gray-shaded regions represent the 11-day time points after irradiation. The red-shaded miRNAs represent the miRNAs used for the antagomir experiments in (B) and (C).

    Journal: Cell reports

    Article Title: Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development

    doi: 10.1016/j.celrep.2020.108448

    Figure Lengend Snippet: (A) Quantification of miRNAs from a 3D culture of mature human microvessels with human umbilical vein endothelial cells (HUVECs) irradiated with 0.5 Gy of simplified simulated galactic cosmic rays (SimGCRSim) compared to sham irradiated samples 48 h after irradiation. All candidate miRNAs were examined, but only the miRNAs that seemed to respond differently for each group are shown. The error bars represent SEM. (B and C) Mature microvessels fixed and fluorescently stained with 5-(4,6-dichlorotriazinyl) aminofluorescein (DTAF) 48 h after SimGCRSim irradiation with or without antagomir-induced inhibition of miR-125b, miR-16, and let-7a starting at 24 h prior to irradiation. Scrambled version of the antagomir was used a vehicle control. (D) Summary of all the fold-change values for all experiments utilized in this manuscript (including both ddPCR and miRNA-seq data). (E) The summary of the overall impact of the miRNAs on the gene targets determined in through pathway analysis on the miRNA-seq data. The arrows indicate the degree of up- or downregulation, and the colors of the arrows indicate the significance (i.e., p values). The gray-shaded regions represent the 11-day time points after irradiation. The red-shaded miRNAs represent the miRNAs used for the antagomir experiments in (B) and (C).

    Article Snippet: Irradiations were carried out at Brookhaven National Lab using 50cGy of SimGCRSim (5-ion simplified galactic cosmic ray simulation: protons at 1000MeV, 28 Si at 600 MeV/n, 4 He at 250 MeV/n, 16 O at 350 MeV/n, 56 Fe at 600 MeV/n, and protons at 250 MeV).

    Techniques: Irradiation, Staining, Inhibition, Control